Preeclampsia and Consanguinity

  • Wisam Akram Gynecology And Obstetrics, AL Yarmook Teaching Hospital – AL Mustasiriyah Medical College
  • Fatin Al Defer Gynecology and Obstetrics, Al Yarmook Teaching Hospital Teaching Hospital

Abstract

Type of the study: case control


Aim: to evaluate the severity of imminent preeclampsia in consanguinity versus non consanguinity groups


Design and patients methods: a highly selective criteria have been chosen for the women to be participated in this study. The study group (N=30) were not only cousins rather their parents were also cousins and most came from the rural area. While the control Group (N=30) were women in whom no consanguinity neither with couple nor their parents were selected. All women were primigravida 20- 30 years in age. They were all taken from labor ward after 37 weeks of gestation, and for each at admission systolic, diastolic blood pressure, serum uric acid, blood urea, blood platelets count and serum fibrinogen and SGPT with SGOT were initially taken at admission. Since all the patients were in severe and imminent preeclampsia they were all pre prepared with MgSO4 as anti convulsant and during preparation serial reading were also taken for all the above parameters at 3 and 6 hours later to measure the area under curve profile AUC. Mean blood pressure was taken instead of systolic and diastolic and calculated by the well documented formula


Results: The ODD ratio for the primary determinant of preeclampsia severity namely blood pressure and proteinurea were higher in the consanguinity group versus control; 6.58 for systolic; 6.73 for diastolic and 4.07 for protein/ creatinine ration in urine, respectively. Serum uric acid and blood urea was also higher for their ODD ratio in the consanguinity group; 5.2 and 5.21 respectively. More importantly the markers of imminent preeclampsia were also significantly higher in the consanguinity group with odd ratio 2.22and 2.61 for SGOT and SGPT respectively. Best subset regression was calculated for the best combination which correlates with mean blood pressure and serum SGPT with Blood urea combinations were having the lowest coefficient of Mallow (Cp); 32.23. From that independent variable a prediction table has been constructed to sort out all the patients with imminent preeclampsia who are most affected and near complications probably and expressed as column of intervals of blood urea with corresponding 1,2.5, 5, 10, 90, 95,97.5 and 99 centile of serum SGPT. The area under 10th centile was shaded with green while above 90th centile with red and in between shaded with yellow color. It is probable that patients who’s reading in the red zone or upper yellow zone are at more risk for more serious complications of preeclampsia like adrenal hemorrhage and renal complications and better to expedite their delivery. Conclusion: this study has shown that preeclampsia among consanguinity group was much more severe than those in non consanguinity couples. Yet by no mean that respect reflects the true picture in society. A table has been constructed and we over stress here that under no circumstances this table can be used for evaluating, modifying or changing the routine protocol of preeclampsia management

Published
2018-02-05
How to Cite
AKRAM, Wisam; AL DEFER, Fatin. Preeclampsia and Consanguinity. Mustansiriya Medical Journal, [S.l.], v. 16, n. 3, p. 1-10, feb. 2018. ISSN 2227-4081. Available at: <http://mmj.uomustansiriyah.edu.iq/index.php/MMJ/article/view/104>. Date accessed: 19 oct. 2019. doi: https://doi.org/10.26903/mmj.v16i3.104.
Section
Articles