The Role of Serum Fucose, Protein Bound Fucose and Other Biomarkers in Patients with Rheumatoid Arthritis

  • Abbas Toma Joda Department of Internal Medicine, College of Medicine, Al-Mustansiriyra University, Baghdad, Iraq

Abstract

Background: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks synovial joints. Aims:  To evaluate the status of serum fucose and protein bound fucose, anti-CCP, TNF-α and RF in serum of RA patients. Subjects and methods: The study has included 30 patients with early RA (with disease duration <1 year) (23 females+ 7 males) with age range (30-61) years and 30 patients with late RA (with disease duration >1 year) diagnosed according to the 2010 EULAR criteria (25 females, 5 males) with age range (30-60) and 28 healthy control individuals (22 females,6 males) with age range (30-55), who were age and sex matching with patients. Results: Levels of total serum fucose and protein bound fucose significantly decrease in RA patients than healthy control, while anti-CCP, TNF-α, RF, CRP and ESR significantly increase in RA patients than healthy control. Levels of total serum fucose, protein bound fucose & ACCP were not significant between three stages of activity in late & early RA patients.  The level TNF-α & RF were significant only in very active cases in late RA, while not significantly in all cases of early RA.  Positive correlation was found between ACCP & ESR in RA patients & early RA patients. Positive correlation found between TSF & PBF, negative correlation found between TNF-α & ESR in late RA patients. Positive correlation found between ACCP & ESR, CRP & ESR in early RA patients. Conclusions: This study illustrate that total serum fucose and protein bound fucose aid to diagnosis RA patient. Also Anti-CCP is a good & specific marker for diagnosis of RA,it is a good prognostic and as index test of severity

Published
2018-02-05
How to Cite
JODA, Abbas Toma. The Role of Serum Fucose, Protein Bound Fucose and Other Biomarkers in Patients with Rheumatoid Arthritis. Mustansiriya Medical Journal, [S.l.], v. 16, n. 3, p. 56-61, feb. 2018. ISSN 2227-4081. Available at: <http://mmj.uomustansiriyah.edu.iq/index.php/MMJ/article/view/111>. Date accessed: 08 dec. 2019. doi: https://doi.org/10.26903/mmj.v16i3.111.
Section
Articles