The Effects of Glucosamine Sulphate on Mice Skin

  • Maan M. Salih
  • A. Ah. Al-Naimi


Glucosamine is an amino monosaccharide derived from cellular glucose metabolis and it is a simple component or "building block" of more complex molecules. Glucosamine was considered to be an effective treatment for many joint diseases especially osteoarthritis. 

It is believed that glucosamine maintain healthy joint functions and rebuild damaged joint cartilage, tendons, ligaments and other connective tissue. It does this by stimulating the production of glycosaminoglycans (GAG’s) which are the structural components of cartilage and connective tissue else where in the body. 

Twenty male and twenty females adult mice (weighting between 23.3gm to 27.2gm), were divided into two equal subgroups (control and experimental); the drug was given at noon three hours after starvation it had been grinded and mixed with food and given as a single oral dose of 350mg/kg body weight per day for 35 successive days. Histological examination and statistical analysis of multiple sections of ventral and dorsal skin of male and female mice and of both subgroups were done by using hemotoxyline and eosin stain.

The results reveal that there was increment in the number of fibroblast which was more obviously seen in the ventral skin of the treated animals. This study confirms practically that glucosamine sulphate induces significant structural changes in the skin of mice. 

Using glucosamine sulphate clinically for medical conditions rather than arthritic diseases is now the target of most recent researches, its ability to decrease wrinkles in the aged skin and promotion of wound healing with less scar tissue is consider to be a light for dermatologist and plastic doctors, plus its effect to rebuild any aged, injured and diseased tissue in the body.  

How to Cite
SALIH, Maan M.; AL-NAIMI, A. Ah.. The Effects of Glucosamine Sulphate on Mice Skin. Mustansiriya Medical Journal, [S.l.], v. 6, n. 1, p. 49-57, aug. 2017. ISSN 2227-4081. Available at: <>. Date accessed: 20 oct. 2020.