A clinicopathological review of amiodarone-induced thyroid disorders

Abstract

Certain drugs could disturb physiological function and anatomical structure of thyroid gland and; to some instance, the peripheral thyroid hormone metabolism as part of their adverse reactions. In fact, commonly prescribed drugs including anti-convulsants, non-steroidal anti-inflammatory drugs, Beta-adrenoceptor antagonists, steroid hormones and heparin may produce an abnormal thyroid function test, albeit an absence of detected clinical features for thyroid dysfunction. Therefore, it is recommended to undertake a routine monitoring of thyroid function test, both at baseline and every 3 to 6 months thereafter, in vulnerable individuals (for example, those with thyroid antibodies or euthyroid goiter) receiving such medication.