Risk factors in perforated peptic ulcer disease: Incidence and relation to morbidity and mortality
Background: Today, the hospital admission and surgical management for peptic ulcer disease is largely restricted to the treatment of its complications. Aims: To study the risk factors of perforated peptic ulcer. Patients and Methods: A prospective study of 118 patients presented with perforated peptic ulcers between January 2009 and December 2011 at Al- Yarmouk Teaching Hospital. A detailed history was documented including the proposed risk factors of age, gender, occupation, social habits and associated medical illnesses. Results: The total number of patients was 118 patients. Out of these, 101 were males (86%) and 17 were females (14%); with the male: female ratio being 6:1. Patients in the fourth decade constituted the highest proportion of cases (38%); 78% non-professional employers; 43.2% used ulcerogenic drugs; 72.9% were smokers and 14.4% consumed alcohol. Negative history of peptic ulcer diseases were documented in 64.4%; 19.5% had associated medical; 44% had blood group O and H. pylori infection was positive in 75% of cases. Regarding the risk factors, H. pylori and smoking were more related. Conclusions: Nonprofessional employer males in the fourth decade of life were the commonest in this collection. Combined risk factors of H. pylori and the use of NSAID formed the highest risk. Negative past history, those with group O and smoking were important risk factors in this study. Regarding the relation of risk factors to morbidity and mortality, medical co-morbidities & smoking had significant relation.