Association between preeclampsia and hyperandrogenemia
Background; Insulin resistance and increased serum free testosterone are well known to be associated with preeclampsia Type of study; case control Aim of the study; to compare serum levels of free testosterone among hypertensive preeclamptic women versus control Methods; two groups were constructed from primigravida women taken from labor ward. Study group (N=30) were preeclamptic versus control (n=30). For all women serum testosterone was assayed and compared and correlated to mean arterial blood pressure and other variables in preeclampsia Result; serum free testosterone was significantly higher among women with preeclampsia compared with control 5.00±0.72 versus 1.28±0.97, P < 0.001. No Significant change was found between serum estriol levels in both groups. Analysis of co-variants has shown that fetal gender (Male) has no effect on maternal serum testosterone levels. Conclusions; preeclamptic women in the third trimester have significantly higher free testosterone serum levels than control women. It is not clear yet whether this increase in free testosterone is related to insulin resistance in the placenta or other factors. Further studies are required to explore the significance of increased testosterone levels in the blood with prediction of preeclampsia and assessment of its severity.