Relationship between Leptin and Insulin‐like Growth Factor‐1 in Children and Adolescent with Growth Hormone Deficiency
Background: Growth hormone deficiency (GHD) is suspected in subjects with short stature (SS) and reduced growth velocity in whom other causes of poor growth have been excluded. Insulin‐like growth factor‐1 (IGF‐1) measurements are relatively newer methods for evaluating GHD or GH adequacy. Objective: To study the relation between levels of leptin and IGF‐1 in the children and adolescents in whom GHD was found. Patients and Methods: This study was conducted during the period from June 2013 until the end of March 2014. The patients were attending to the National Diabetic Center/ AL‐Mustansiriya University. Serum IGF‐1 and leptin were measured in children and adolescent with GHD; 56 children with GHD were participated in this study their age range was (5‐17) years, they were compared with 30 healthy children as control group. Results: Means BMI and basal serum levels of GH and IGF‐1 were signiﬁcantly decreased in children and adolescent with GHD when compared with the control group. There was a significant decrease in serum level of IGF‐1 in boys with GHD as compared to girls with GHD, while there was no significant difference in basal GH and leptin between boys and girls with GHD. A significant negative correlation was found between leptin versus BMI and IGF‐1 in both gender groups, while a significant positive correlation was found between serum IGF‐1 versus BMI and GH in children with GHD. Conclusions: The present results are consistent with the hypothesis that leptin could contribute to the regulation of GH secretion and IGF‐1 concentrations.